You can go to Niseko from both Sapporo and New Chitose Airport.
(1)From Sapporo
2 Buses run from Sapporo, and the fee is 4500 yen (round trip).
(2)From the New Chitose Airport
7 buses run, and the round trip fee is 8000 yen, and you can directly go there from the airport.
You have to reserve this in advance.
Selecting one way to Sapporo and the other way to the airport is possible. The fee is culculated as a round trip.